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On 28 March, 2012, scientists from China, Japan, the United States and the United Kingdom (forming the CEOT) met in Shanghai to outline a strategic plan that will create and use 21st century scientific data to guide industry towards manufacturing “safe products” by helping to set justified levels of chemical exposure.

The meeting was driven by a broad consensus that current 20th century practices of toxicity testing by using mammalian models need replacing by more mechanistically-based and cost-effective alternatives. Until recently, the prohibitive costs and questionable relevance of current methods of toxicity assessment have resulted in an exorbitant “control dilemma” for the >60,000 synthetic compounds used by households and industry and now for emerging advanced materials. All require evaluation of their health effects (let alone their interactions as mixtures across environmentally relevant concentrations). Yet now, with DNA sequencing and computing power plummeting in price as the science develops, rapid technological improvements are transforming the possibilities for regulatory toxicology.

Since 2012, meetings are held in Shenzhen (China), Bloomington (USA), Birmingham (UK), Brussels (Belgium), Paris (France), Ispra (Italy), Canberra (Australia), Raleigh and Washington (USA), Karlsruhe (Germany), Okasaki (Japan) that continue to build international participation in this project.



Environmental Omics is conceived with the knowledge that there are times in every field of science when technological advance sets the stage for progress at a pace that was previously inconceivable. The application of 21st Century technologies towards environment and health protection through shared, publicly owned, knowledge for the development of safer commercial products and for effective implementation of environment and health regulations will promote not only public well-being, but also the economy and job creation in the global markets, including competitiveness across industries and service sectors.